Teaching

This compulsory lecture deals with mechanistic aspects of organic chemistry. It is organized according to reaction types: Nucleophilic substitutions, eliminations, electrophilic aromatic substitutions, nucleophilic aromatic substitutions, reactions of the carbonyl group, pericyclic reactions. Reactive intermediates such as carbenium ions, carbonium ions, carbenes, nitrenes, ylides etc. are dealt with.

Recommended literature:

R. Brückner, Reaction Mechanisms

J. March: Advanced Organic Chemistry

Recommended supplementary lecture:

Name reactions

The purpose of this lecture is to provide for students an overview dealing with (bio)organic materials from natural sources, their chemical modifications and applications, as the field of biomaterials has grown considerably during the last decades. Seemingly, the term "biomaterials" is not well-defined. On the one hand, experiences gained in clinical uses of materials, the replacement of diseased or missing body parts by man-made materials, and tissue-engineering, on the other hand structure-properties relationships and degradation of materials are portions of that field. We, however, put a strong emphasis on the organic and biochemical aspects to understand the fundamentals of biomaterials and biopolymer research.

Chapter I deals with peptide- and protein-based materials including peptide-nanomaterials, stimulus-responsive peptide-based materials, coiled coils, synthetic collagen mimics, and spider silk related materials.

Chapters II to IV cover portions of carbohydrate-based materials (cellulose, starch, functional polymers from sugars, glyconanomaterials), polyketide-based materials, and modified nucleic acids, respectively.

Literature

J. Park, R. S. Lakes, Biomaterials, An Introduction, 3rd edition, 2010, Springer.

B. D. Ratner, A. S. Hoffman, F. J. Schoen, J. E. Lemons, Biomaterials Science, 2nd edition, 2004, Elsevier Academic Press.

The lecture is part of the module "Syntheses and Mechanisms" in the Master's degree program in Chemistry. It deals with the mechanisms, the range of application and limitations of modern name reactions that are used in current synthetic chemistry. In the context of this lecture, the individual reactions are organized according to synthesis goals, and therefore provide a complementary insight into synthetic chemistry, which is presented in other compulsory lectures of the Master's program and the practical course "Organic Chemistry for Advanced Students". Chapters of this lecture are C-C and C=C bond linkages, reactions on non-activated C-H bonds and defunctionalizations.

The lecture is part of the compulsory elective program in the Bachelor's degree program in Chemistry and deals with the main classes of important biomolecules (amino acids, proteins, sugars, membrane components, nucleobases) as well as an introduction to the basic metabolisms and cycles of biochemistry (glycolysis, citrate cycle, fatty acid metabolism, amino acid degradation, urea cycle, etc.) and molecular genetics (DNA, RNA, protein biosynthesis) and photosynthesis. The biochemical mechanisms are compared with the reaction mechanisms of synthetic chemistry. Naturally, the functions of important vitamins as well as pharmacological and toxicological aspects are discussed.

During this seminar we are discussing synthetic problems which were taken from the modern literature of organic chemistry. It's always time to discuss problems which arise from the daily laboratory work. From time to time all co-workers present their recent results and give an over-view about their scientific futureplans. Students and guest are always present and are highly welcome (we also speak German).

The seminar is part of the practical course "OCC" (Bachelor). Each participant either gives a presentation on a previously independently solved synthesis problem from the organic chemistry literature or on the content of a current review article. The topics are assigned at the beginning of the semester.

The lecture is intended for students with organic chemistry as a minor subject. The important classes of substances in organic chemistry and the fundamental mechanisms are covered.

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